It is recommended to vaccinate only healthy calves. Using aseptic technique, administer a 2 mL dose subcutaneously in the neck. It is recommended that animals are vaccinated 3 times at 2 to 4 week intervals prior to calving. The third dose should be administered at least 2 to 3 weeks prior to calving. Semi-annual revaccination is recommended. Administer epinephrine in the event of an anaphylactic reaction.